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Coagulation Cascade SIMPLEST EXPLANATION !! The Extrinsic and Intrinsic Pathway of HEMOSTASIS

In this video we are going to talk about the coagulation cascade before beginning make sure you have seen the first part of the video which explains the clotting factors in detail I will leave a link to that video on the screen right now be sure to watch that video for a better understanding of this topic let’s first have an overview regarding what happens in the copulation cascade so we have a intrinsic pathway and then we have an extrinsic pathway they both eventually lead to the formation of prothrombin activator which is actually the activated factor 10 once prothrombin activator is activated it in the presence of calcium ions it converts prothrombin to thrombin and when sufficient quantity of thrombin is formed in the blood it leads to the conversion of fibrinogen into fibrin but initially these fibrin are just monomers and they cannot form a stable plot so in the presence of calcium ions the fibrin stabilizing factor which is actually the factor number 13 it acts on them and converts them into fibrin polymers by formation of covalent bonds in the fibrin monomers and eventually they lead to the formation of a clot by attracting lots of platelets lots of phospholipids and other materials which add hers on them and form the stable clot which plugs the bleeding site and leads to hemostasis let’s first talk about the extrinsic pathway so the extrinsic pathway begins with any factor which causes tissue trauma now this drama can be trauma to the vascular wall itself or it can also be a trauma to the extra vascular tissue and this causes the release of the tissue factor also known as tissue thromboplastin now this tissue factor causes the conversion of factor number 7 to activated factor number 7 and then the tissue factor combines with the activity factor 7 in the presence of calcium ions and causes the conversion of factor number 10 to activated factor number 10 and then the factor number 10 which is activated in the presence of calcium ions and number five forms the prothrombin activator and arrests events are the same that is the program in activator causes the conversion of prothrombin to thrombin now let’s talk about the intrinsic pathway intrinsic pathway begins with any factor which causes trauma to the blood cells directly or causes the exposure of the blood cells to collagen this causes activation of factor number 12 so when the factor number 12 is activated it acts upon the factor number 11 and causes its activation that is 11a and this 11 a factor acts upon the factor number 9 and forms the factor number 9 a and these reactions require some cofactors such as the high molecular weight Keynesians and calcium ions and undi 9 which is activated in the presence of factor number 8a which is derived from fact number 8 it combines with calcium ions and causes the activation of fact number 10 and then the events are almost same as that of the extrinsic pathway that is combination of the activated factor 10 to calcium ions and factor 5 and formation of a prothrombin activator and the Protomen activator subsequently acting on the prothrombin and formation of thrombin so to summarize what happens in the coagulation cascade we have the intrinsic pathway and the extrinsic pathway they both ultimately lead to the formation of a prothrombin activator that is activated factor 10 and this causes the formation of thrombin from prothrombin and the thrombin acts on fibrin ocean to form fibrin monomers but these monomers are not stable and they cannot form a clot so the fibrin stabilizing factor which is the factor number 13 it acts upon the fibrin monomers and forms a lot of covalent bonds between the fibrin monomers and this leads to the formation of a fibrin mesh and this mesh attracts platelets phospholipids and forms a stable blood clot which causes hemostasis so this was pretty much all about the coagulation cascade I hope you find this video informative make sure to hit the like button below and also subscribe to our channel we have tons of upcoming videos on hematology gastroenterology and many other topics so make sure to hit the subscribe button to have a regular update about those videos also make sure to like us on Facebook we discuss lots of tips tricks and lots of mnemonics regarding studies anyways thank you for watching this video